PhD from the University of Zaragoza (1991, supervisors Prof J. Forniés and Prof. R. Navarro), with a 16-month postdoctoral stay at the University of Strasbourg under Prof. Michel Pfeffer (1993-94). Returned to ICMA (a joint center of CSIC and the University of Zaragoza) as a contracted researcher (1994-96, 1997-99). Permanent position as a Tenured Scientist at ICMA (2000-07) and promotion to Research Scientist in 2007 (ICMA, since 2011 part of ISQCH). Since 2021, I am Deputy Director of the Institute of Chemical Synthesis and Homogeneous Catalysis (ISQCH; CSIC-University of Zaragoza), re-elected for the 2025 term. I was the scientific head of the NMR service (2003-2007) and have been in charge of the Elemental Analysis service (2008-2024) at CEQMA (Zaragoza).
From 2004 to 2023, I have been Principal Investigator (PI) of two independent research groups (Molecular Activation through Organometallics from 2011-2016, and Amino Acids and Peptides from 2019-2023), leading all funded research projects from the academia and also from industry, totaling 20 years as an independent PI and more than €500,000 in research funding. I published more than 155 scientific papers (cited 4165 times, H = 36), I was Guest Editor of a volume of Current Organic Chemistry (2011, Vol. 15, No. 18), and I belong to the Editorial Board of Journal of Chemistry (Wiley) since 2012 and of Molecules (MDPI) since 2019. I have been invited many times to give guest lectures at national and international universities (16). I have presented more than140 contributions at national and international conferences, most of them oral presentations since 2012. I have supervised several postdoctoral contracts (Juan de la Cierva, JAEDoc) and 10 PhD students, as well as numerous master and degree's students. I am an evaluator for research projects, grants, and infrastructure proposals in Spain, the USA, France, Argentina, and Romania, and I review manuscripts for over 20 JCR/SCI-indexed journals.
Research Lines and Main Achievements
- Functionalization of high value-added molecules through metal-mediated C-H bond activation (1993-present)
- Photochemical synthesis of high value-added compounds catalyzed or mediated by transition metals (2005-present)
- Luminescence of organometallic species (2016-present). In all these lines, our main focus is on amino acids, bis-amino acids, their precursors, and derivatives, and we will continue developing these approaches in the future.
(a) Using late-stage
C-H bond activation strategies, we have functionalized phenylglycines
via Ru catalysis (J. Mol. Catal. A: Chem. 2017, 426, 407),
phenylalanines and dehydroaminophosphonates via Pd catalysis (J. Org. Chem.
2015, 80, 3321; Eur. J. Org. Chem. 2024, e202400146),
and phenylglycines vis stoichiometric Pd-mediated processes (J. Organomet.
Chem. 2020, 925, 121482; Molecules 2025, 30,
236). We developed a general method for the synthesis of fused heterocycles
using Ru catalysis (J. Org. Chem. 2013, 78, 5254; Synfacts
2013, 9, 0943; Chem. Eur. J. 2015, 21, 8626;
Org. Lett. 2015, 17, 3178; Org. Biomol. Chem. 2017,
15, 8904; Org. Biomol. Chem. 2019, 17, 2542), and a
method for the synthesis of tetrasubstituted alkenes via Cu-promoted
acetoxythiolation of internal alkynes (Chem. Eur. J. 2018, 24,
13124). Reviews: ChemCatChem 2025, e01931; Tetrahedron
Lett. 2016, 57, 3413; C-H and C-X Bond Functionalization
(Editor: Xavi Ribas, RSC Catalysis Series 11, 2013); Comments Inorg. Chem.
2012, 33, 55.
(b) Photochemical
reactions are currently one of our main
research topics. The [2+2] photocycloaddition of C=C double bonds in 4-arylidene-5(4H)-oxazolones
was unprecedented. We developed two complementary methods for the synthesis of
bis-amino acid derivatives of 1,3-diaminotruxilics-compounds with
pharmacological activity—via [2+2] cycloaddition. One method involves orthopalladation
of the oxazolone via C-H activation using Pd complexes as templates (Chem.
Commun. 2009, 4681; Inorg. Chem. 2011, 50,
8132; Chem. Eur. J. 2016, 22, 144 - cover article; Eur.
J. Inorg. Chem. 2019, 3481; Beilstein J. Org. Chem. 2020,
16, 1111). This approach provides 1,3-diaminotruxilic derivatives in a
stereoselective manner. The other method is based on (photo)sensitized or
direct irradiation of the oxazolones with monochromatic light (ACS
Sustainable Chem. Eng. 2017, 5, 8370; J. Org. Chem. 2021,
86, 12119; J. Org. Chem. 2022, 87, 3529; Org.
Biomol. Chem. 2023, 21, 3203; Int. J. Mol. Sci. 2023,
24, 7583).
(c) Regarding luminescence,
we are developing palladium organometallics that enhance the fluorescence of
natural chromophores derived from GFP through orthopalladation and
conformational restriction (Eur. J. Inorg. Chem. 2018, 6158; Molecules
2021, 26, 1238; Org. Biomol. Chem. 2021, 19,
2773; Inorg. Chem. 2023, 62, 9792; Dalton Trans. 2024,
53, 8948; Inorganics 2024, 12, 271). Review: Molecules
2023, 28, 2663.
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